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Thesis

Thesis

Fall 2025

The AI discovery engine.

AI

About Company

Thesis is building the engine for discovery. Our aim is to help uncover the next AlphaFold or build the next Transformer, faster, more systematically, and at scale. We treat discovery not as a matter of luck, but as an engineering challenge to be solved. Thesis lets anyone build powerful machine learning models for anything they can imagine. The mission is to democratize invention by putting machine intelligence in everyone’s hands. Every major breakthrough in the next decade, in science, industry, or AI, will be built on systems like Thesis. We intend to define that category.

Active Founders

Sergio Charles

Sergio Charles

Founder

Thesis will become the engine for all future AI-driven discovery. Maximally truth-seeking. Prev: AI R&D at Google X, Nvidia and Stanford's AI Lab, working with Andrew Ng and Chelsea Finn. B.S. Math & CS, M.S. Stats Stanford

Luigi Charles

Luigi Charles

Founder

Betting the farm that AI will become meaningful in the discovery of new science. Second time founder. Previously built and scaled global payments infrastructure from zero to billions. BS. Columbia Math & CS. Zero hedge. Thesis is inevitable.

Company Facts

LocationSan Francisco, CA, USA
Team Size2
Founded2025
StatusActive